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Many such papers regarding Alzheimer's disease and Parkinson's Disease have been published. A plausible explanation for these cases may be the effect of smoke, a cholinergic stimulant, decreasing the levels of acetylcholine in the smoker's brain; Parkinson's disease occurs when the effect of dopamine is less than that of acetylcholine. Opponents counter by noting that consumption of pure smoke may be as beneficial as smoking without the risk.

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